Learn about drug interactions between prednisone oral and warfarin oral and use the RxList drug interaction checker to check drug combinations. Methylprednisolone, prednisone, and warfarin are substrates for metabolism by the CYP3A4 isoenzyme pathway. The inhibition of warfarin metabolism. SAN FRANCISCO – The main reason older U.S. adults are hospitalized for drug interaction is an interaction with warfarin, so watch out for. The intervention group's warfarin dose was reduced by a median of Drug Interaction Classification These classifications are only a guideline. Beware warfarin interaction with antibiotics, acetaminophen, steroids. Secondary outcomes included INR control, purchases of prescription vitamin K, and warfarin-associated adverse events in the 30 days after prednisone initiation. There have been reports of patients who experienced bleeding complications and increased INR or bleeding times after consuming large quantities of cranberry juice, mangos, grapefruit, grapefruit juice, grapefruit seed extract, or pomegranate juice. Subscribe to Drugs. To evaluate the utility prdenisone preemptive warfarin dosage adjustment for preventing non-therapeutic INR following prednisone-warfarin co-administration. Therefore, it is important to keep your vitamin supplement and substance provigil controlled intake steady throughout treatment. Since this patient did not use tobacco or consume alcohol and had a fairly consistent dietary intake of vitamin K, these variables were ruled out read more influencing the INR. Subjects received a follow-up INR within 7 days. Secondary end points included bleeding events, emergency department visits, hospitalizations, and warfarin dose modifications. Highly clinically significant. For example, increasing vitamin K levels in the body can promote clotting and reduce the effectiveness of warfarin.